Age-Related Macular Degeneration by D. Virgil Alfaro III et al.

By D. Virgil Alfaro III et al.

Stay modern with the most recent advancements on your box with the highly-anticipated moment variation of Age-Related Macular Degeneration. This finished textual content covers fresh advances in pathophysiology, prognosis, and remedy together with promising new advancements that may impact your sufferer care. Dr. Virgil Alfaro and his colleagues at Retina experts of Charleston carry you their services within the components of easy technology, imaging, prevention, remedy, and more.

  • Learn from a well known team of retina surgeons who tackle all facets of administration, together with anatomy, body structure, and pathophysiology; imaging of the macula in ARMD, prevention measures and remedy; and destiny instructions within the field.
  • Gain a superb beginning in intravenous fluorescein angiography, indocyanine eco-friendly angiography, and optical coherence tomography, in addition to antiVEGE remedy and similar new medicinal drugs, optimizing your analysis and remedy options.
  • Understand the numerous switch within the category approach of choroidal neovascular membranes in ARMD.
  • Get updated info on treating ARMD secondary to geographic atrophy via phone transplantation and pharmacologic therapies.
  • Easily visualize key points of ARMD because of fine quality illustrations and photographs.
  • Find the knowledge you would like quick by way of referencing person chapters that supply finished and inclusive assurance of the subject at hand.
Now with the print version, benefit from the bundled interactive publication variation, providing capsule, phone, or on-line entry to:
  • Complete content material with improved navigation 
  • Powerful seek instruments and clever navigation cross-links that pull effects from content material within the publication, your notes, or even the web
  • Cross-linked pages, references, and extra for simple navigation
  • Highlighting device for simpler reference of key content material in the course of the text
  • Ability to take and percentage notes with acquaintances and colleagues
  • Quick reference tabbing to avoid wasting your favourite content material for destiny use

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Example text

At 3 months, the short-term group showed deposition of complement component C3d in BM, RPE swelling and lysis, sub-RPE deposits, pyknosis of overlying photoreceptors, and invasion of macrophages. Longterm counterparts, on the other hand, exhibited a three- to fivefold thickening of BM. There existed a solid correlation (c) 2015 Wolters Kluwer. All Rights Reserved. 20 SECTION 1 ANATOMY, PHYSIOLOGY, AND PATHOLOGY OF THE MACULA between the levels of CEP-specific antibodies and the severity of pathologic alterations.

Francis et al. (169) genotyped a population of rhesus macaques and found that a susceptibility locus in the rhesus homologue of human 10q26 was associated with macular phenotype. These genes contain sequence variants significantly associated with affected status in humans and macaques. As expected, the LOC387715/ARMS2 gene is present in simians only, thus corresponding with development of the macula. In contrast to human studies, this study indicated that only the promoter polymorphism in HTRA1 appears to be significantly associated with the disease phenotype.

Undoubtedly, one of the most seductive advantages of murine models is the ease to manipulate them genetically, surgically, and pharmacologically. The aforementioned dry AMD murine models can be conveniently classified into three categories: ■■ Genetically engineered mice ■■ Immunologically manipulated mice ■■ Naturally occurring mouse strains Most murine models are genetically engineered to manipulate genes that are suspected to cause macular degeneration-like disorders in humans or might be somehow associated to AMD pathogenesis.

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