Antiepileptic Drugs: Pharmacology and Therapeutics by F. E. Dreifuss, N. B. Fountain (auth.), Professor Mervyn J.

By F. E. Dreifuss, N. B. Fountain (auth.), Professor Mervyn J. Eadie AO, MD, PhD, Dr. Frank J. E. Vajda M.D. (eds.)

In 1985, quantity seventy four of the Springer-Verlag instruction manual of Experimental Phar­ macology, lower than the editorship of H. -H. Frey and D. Janz, seemed. during this quantity the then to be had facts concerning antiepileptic medications have been col­ lated and analysed. Over the intervening years wisdom during this sector has grown steadily. extra new antiepileptic medicines than the entire variety of brokers that have been in universal use 15 years in the past have within the period both come directly to the industry or are approximately to take action. besides, additional brokers are at a pretty complicated level of improvement, while the already verified medications have most commonly held their locations in scientific perform. wisdom of epileptogenesis has complicated significantly. The mechanisms of motion of antiepileptic medicinal drugs on the molecular point and in a number of animal versions of epileptic seizures and of the epileptic kingdom are far better understood than they have been formerly. besides, additional information is accessible about the average heritage of human epilepsy, and this information is critical in making optimum use of some of the brokers which are now on hand. as a result, it has appeared acceptable at this degree within the evolution of data to supply a moment quantity facing Antiepileptic medications within the instruction manual of Experimental Pharmacology series.

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Extra resources for Antiepileptic Drugs: Pharmacology and Therapeutics

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1. Interactions Between Anticonvulsant Drugs ........... 2. Interactions Between Anticonvulsant Drugs and Other Drugs ...................................... G. Conclusions .............................................. References .................................................. l EADIE . . . . . . . . . . . . . . . . . . . . . . . . . . 589 XXXVIII Contents A. Introduction .............................................. B. Changes in Antiepileptic Drug Use for Epilepsy ...............

In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, Vol 15, North Holland, Amsterdam, pp. 219-234 Kellaway P, Hrachovy RA, Frost JD et al. (1979) Precise characteristics and quantification of infantile spasms. Ann NeuroI6:214-218 Landau WM, Kleffner FR (1957) Syndrome of acquired aphasia with convulsive disorder in children. Neurology 7:523-550 Lennox WG (1966) The slow-spike-wave EEG and its clinical correlates. In: Lennox WG (eds) Epilepsy and related disorders. 156-170 Lennox WG, Davis JP (1949) Clinical correlates of the fast and the slow spike and wave electroencephalogram.

9. Clobazam ........................................ a) Interactions Affecting Clobazam .................. b) Interactions Where Clobazam Affects Other Drugs......................................... II. Pharmacodynamic Interactions ........................ 1. Interactions Between Anticonvulsant Drugs .......... 2. Interactions Between Anticonvulsant Drugs and Other Drugs ...................................... 567 567 567 567 567 569 569 569 569 569 570 570 570 570 570 571 571 571 571 571 572 572 573 573 573 573 573 574 574 574 574 575 575 575 575 575 576 Contents XXXVII F.

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