Astrocytes. Pharmacology and Function by Sean Murphy (Auth.)

By Sean Murphy (Auth.)

Curiosity within the sensible roles of astrocytes within the fearful procedure has grown considerably because it is well-known that those cells not just have their very own pharmacology but in addition unencumber neuro- and vaso-active elements. This publication relates astrocyte pharmacology to mobilephone functionality for the 1st time, making it an enticing textual content around the neuroscience community.* Discusses the pharmacological legislation of specific Read more...

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Calciu m w a v e starting to sprea d 1 se c afte r a cel l in the cente r o f the imag e ha s bee n p r o b e d with a micropipette. C, D. Take n 7 a n d 1 6 sec , respectively , afte r the initial p r o b e . Ba r = 5 0 /xm. b e t w e e n astroglia (Fig. , 1 9 9 1 ; Enkvist a n d M c C a r t h y , 1992). , 1991). T h e possibility t h a t astrocytes in b r a i n m a y c o m m u n i c a t e over large distances a n d t h a t such c o m m u n i c a t i o n m a y b e r e g u l a t e d by n e u r o l i g a n d s is relatively n e w a n d will r e q u i r e m o r e studies to assess t h e i m p o r t a n c e of this p h e n o m e n o n in b r a i n function.

Cells a t restin g calciu m befor e the experiment . B. Calciu m w a v e starting to sprea d 1 se c afte r a cel l in the cente r o f the imag e ha s bee n p r o b e d with a micropipette. C, D. Take n 7 a n d 1 6 sec , respectively , afte r the initial p r o b e . Ba r = 5 0 /xm. b e t w e e n astroglia (Fig. , 1 9 9 1 ; Enkvist a n d M c C a r t h y , 1992). , 1991). T h e possibility t h a t astrocytes in b r a i n m a y c o m m u n i c a t e over large distances a n d t h a t such c o m m u n i c a t i o n m a y b e r e g u l a t e d by n e u r o l i g a n d s is relatively n e w a n d will r e q u i r e m o r e studies to assess t h e i m p o r t a n c e of this p h e n o m e n o n in b r a i n function.

I. Pharmacological studies o f [1251] pindolol binding o f individual astroglial cells. Brain Res. 3 3 5 , 1 - 9 . Burgess, S. , T r i m m e r , P. , a n d McCarthy, K. D . (1985). Autoradiographic quantitation of beta-adrenergic receptors o n neural cells in primary cultures. II. Comparison o f recep­ tors o n various types o f i m m u n o c y t o c h e m i c a l l y identified cells. Brain Res. 3 3 5 , 1 1 - 1 9 . Charles, A. C , Merrill, J. , Dirksen, E. J. (1991). Intercellular signaling in glial cells: Calcium waves and oscillations in r e s p o n s e to mechanical stimulation and glutamate.

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