Atherosclerosis And Oxidant Stress - A New Perspective by Walter Hendelman M.D.

By Walter Hendelman M.D.

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P. Erlinger 18. Miller ER III, Erlinger TP, Sacks FM, Svetkey LP, Charleston J, Lin P-H, Appel LJ. A dietary pattern that lowers oxidative stress increases antibodies to oxidized LDL: results from a randomized controlled feeding study. Atherosclerosis 2005;183:175–182. 19. Moreno JJ. 7. Free Rad Biol Med 2003;35:1073–1081. 20. Moreno JJ, Mitjavila MT. The degree of unsaturation of dietary fatty acids and the development of atherosclerosis (Review). J Nutr Biochem 2003;14:182–195. 21. Obarzanek E, Sacks FM, Vollmer WM, Bray GA, Miller ER, III, Lin PH et al.

12. Ancel K. Coronary heart disease in seven countries. New York: American Heart Association Monograph Number 29. 1970. 13. Knoops KTB, de Groot LCPGM, Kromhout D, Perrin A-E, Moreisas-Varela, Menotti A, van Staveren WA. Mediterennanean diet, lifestyle factors, and 10 year mortality in elderly European men and women. JAMA 2004;292:1433–1439. 14. Kratz M, Cullen P, Kassner F, Fobker M, Abuja PM, Assmann G, Wahrburg U. Effects of dietary fatty acids on the composition and oxidizability of low-density lipoprotein.

The Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study was the first large-scale randomized trial of antioxidant vitamins in a well-nourished population. 1 years, vitamin E supplementation did not reduce the risk of lung cancer (the primary endpoint). 6 years. 56). The negative result may have been due to insufficient statistical power or inadequate dosing of vitamin E. 33 Vitamin E supplementation increased plasma vitamin E levels, decreased circulating oxidized LDL and decreased LDL oxidative susceptibility, but there was no difference in the primary endpoint of progression of common carotid artery intima-media thickness.

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