Biophysical Thermodynamics of Intracellular Processes: by Lev A. Blumenfeld, Alexander N. Tikhonov

By Lev A. Blumenfeld, Alexander N. Tikhonov

The most aim of this publication is to explain in actual phrases the strange positive aspects of "machines" having molecular dimensions that play the vital function within the most crucial organic tactics, viz., power transduction and enzyme catalysis. on the grounds that those molecular engines paintings with thermal, chemical, and mechanical power, the perfect framework to debate them comes from thermodynamics and chemical kinetics. The booklet hence starts off with a evaluate of the thermodynamics and chemical kinetics. It then discusses the idea of molecular machines, and specifically, the issues linked to employing thermodynamics to small platforms resembling enzymes. The authors then flip to enzyme catalysis, discussing theoretical and experimental investigations of protein dynamics. The concluding bankruptcy bargains with strength transduction in organic membranes, concentrating on ATP synthesis.

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Cambridge. MA. 24. V. WesterhotT and K. van Dam (1979). In: Current Topics in Bioenergetics (D. Rao Sanadi. ). Vol. 9. • New York. pp. 1-62. 25. V. WesterhotTand K. van Dam (1987). Thermodynamics and Control of Biological Energy Transduction. ElsevierfNorth-Holland. Amsterdam. 26. R. Caplan and A. Essig (1983) Bioenergetics and Linear Nonequilibrium Thermodynamics. Harvard University Press, Cambridge, MA. 27. P. Glansdorf and I. Pigogine (1971), Thermodynamic Theory of Structure, Stability and Fluctuations, Wiley-Interscience, London.

Shall produce no effect other than the extraction of heat from the reservoir and the performance of an equal amount of mechanical work" (cited in [7]). According to McClare [3], this formulation is inadequate in biology. The classical statement of the Second Law does not contain time. Having been stated more than 100 years ago, this formulation did not, of course, take into account the internal peculiarities of molecules nor their atomic constitution. Meanwhile, the atomic structure of biopolymers cannot be ignored in explaining the energetics of molecular machines.

Blumenfeld (1981). Problems of Biological Physics. Springer-Verlag. Heidelberg. 4. Th. De Donder (1927). L'affinite. Gauthier-Villars. Paris. 5. H. Johnson. H. J. Polissar (1954). The Kinetic Basis of Molecular Biology. Wiley. New York. 6. W. Atkins (1983). Physical Chemistry. Oxford University Press. Oxford. 7. G. Van Kempen. Stochastic Processes in Physics and Chemistry. NorthHolland. Amsterdam. 8. R. Welch (1985). J~ Theor. Bioi. 433-446. 9. W. Gibbs (1902). Elementary Pinciples in Statistical Mechanics.

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