By Packer L.
This targeted, state of the art reference offers an in depth account of the molecular mechanisms underlying the a number of services of biothiols-emphasizing the organic and medical implications of interactions among oxidants and biothiols.
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Extra info for Biothiols
A. Freeman, Biochem. J. 290, 51 (1993).  KINETICS OF THIOL REACTIONS 51 radical cations. The absolute rate constant for this reaction (17) has been measured with the stopped-flow technique. 35 Aminopyrine, A P [4-(dimethylamino)-l,2-dihydro-l,5-dimethyl-2-phenyl-3H-pyrazol-3-one], is a common drug that undergoes enzymatic oxidation (by horseradish peroxidase 36 and prostaglandin H synthase 37) to the respective radical cation, A P t . The UV/Vis spectrum of the latter shows two distinct maxima at 325 nm [/3325 = 5350 M -1 cm -1 (Ref.
RSH ~ (nucleic acid)C-OH + RSO. (21) (22) Thiol as Nucleophile Conventional Ultraviolet Spectroscopy In the deprotonated form thiols are strong nucleophiles that react with a variety of electrophiles such as, for example, nitroaromatics or quinones. Most of these reactions can be studied under conditions in which the halflife is on the order of minutes.
This will not always be possible. , other than the thiol used to generate thiyl radicals) is constrained by the need to avoid • O H or Br2: radicals reacting directly with the solute rather than by Eqs. (5) and (6). These kinetic constraints, and the weak optical absorption of most thiyl radicals, together result in much kinetic information concerning thiyl radical reactions being obtained not by directly monitoring the thiyl radical, but by observing some secondary product. This must be produced in a reaction that is not itself rate-limiting.