Blood Medicine: Blowing the Whistle on One of the Deadliest by Kathleen Sharp

By Kathleen Sharp

"Blood Feud competitors A Civil Action for most sensible non-fiction publication of the previous twenty years." — John Lescroart, New York Times bestselling writer of Damage

Procrit appeared like a biotech miracle, promising a golden age in therapy. constructed within the Nineteen Eighties via Amgen and certified to the pharmaceutical big, Johnson & Johnson, the drug (AKA Epogen and Aranesp) quickly generated billions in annual revenue—and nonetheless does. In 2012, international well-known bike owner, Olympian, and travel de France champion Lance Armstrong was once banned from specialist biking on doping fees for utilizing EPO (the blanket identify for the medication Procrit and Epogen), leading to an international controversy approximately abuse, tremendous pharmaceutical businesses, and the lies and inaccuracies touching on performance-enhancing drugs.

Mark Duxbury used to be a J&J salesman who as soon as believed within the blood-booster, atmosphere checklist revenues and successful corporation awards. Then Duxbury began to study unsavory truths approximately Procrit and J&J's company practices. He was once fired and filed a whistleblower swimsuit to warn the public.

When Jan Schlichtman (A Civil Action) discovered of Duxbury's campaign, he signed on. Now, he's battling on behalf of melanoma sufferers and for each American who trusts vast Pharma together with his lifestyles.

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Loscher, W. (2004). Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures. Neuroscience, 123, 751–759. Vorbrodt, A. , & Dobrogowska, D. H. (2003). Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: Electron microscopist’s view. Brain Research. Brain Research Reviews, 42, 221–242. , Linn, D. , & Baer, M. R. (2010). Pim-1 kinase protects P-glycoprotein from degradation and enables its glycosylation and cell surface expression.

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Rigor, R. , & Miller, D. S. (2010). Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay. Journal of Cerebral Blood Flow and Metabolism, 30, 1593–1597. , & Terasaki, T. (2006). Functional characterization of the brain-to-blood efflux clearance of human amyloid-beta peptide (1–40) across the rat blood-brain barrier. Neuroscience Research, 56, 246–252. Juliano, R. , & Ling, V. (1976). A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.

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