By Susan D. Moffatt-Bruce
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Extra resources for Cardiac Transplantation
Sample text
American Journal of Transplantation Vol. 11, No. 2 (February 2011), pp. , & Vo, A. (2009). Intravenous immunoglobulin a natural regulator of immunity and inflammation. Transplantation Vol. 88, No. 1 (July 2009), pp. , et al. (2007). Successful management of antibodymediated cardiac allograft rejection with combined immunoadsorption and AntiCD20 monoclonal antibody treatment: Case report and literature review. Journal of Heart and Lung Transplantation Vol. 26, No. 5 (May 2007), pp. , et al. (1995).
Its cytotoxic effects arise from intra- and interstrand DNA crosslinking, leading to DNA inactivation and cell death; immunosuppression arises from selective suppression of B-lymphocyte activity as well as a general lymphopenia of both B cells and T cells. Theoretically, cyclophosphamide provides the advantage of avoidance of rebound B cell proliferation with more short-term strategies like plasmapheresis and IVIg that do not alter B cell production. 1 Data for cyclophosphamide use in heart transplantation Several small case series have reported success with the use of cyclophosphamide and IVIg for desensitization prior to cardiac transplantation.
Transplantation. Jun 14. [82] Griffith BP, Hardesty RL, Deeb GM, Starzl TE, Bahnson HT. Cardiac transplantation with cyclosporin A and prednisone. Annals of surgery. 1982 Sep;196(3):324-9. [83] Starzl TE, Klintmalm GB, Weil R, 3rd, Porter KA, Iwatsuki S, Schroter GP, et al. Cyclosporin A and steroid therapy in sixty-six cadaver kidney recipients. Surgery, gynecology & obstetrics. 1981 Oct;153(4):486-94. [84] Starzl TE, Klintmalm GB, Porter KA, Iwatsuki S, Schroter GP. Liver transplantation with use of cyclosporin a and prednisone.