By John F. Van Vleet, Victor J. Ferrans (auth.), Thomas Carlyle Jones D.V.M., D.Sc., Ulrich Mohr M.D., Ronald Duncan Hunt D.V.M. (eds.)
This quantity is considered one of a suite of concise, good illustrated and authoritative reviews of usual and experimental lesions of laboratory animals (rat, mouse and hamster) prepared by means of organ platforms. designated differential diagnostic standards and terminology are given emphasis. integrated are helpful facts on pathogenesis, etiology, biologic habit, frequency in numerous lines and lower than various laboratory stipulations.
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Additional resources for Cardiovascular and Musculoskeletal Systems
1987). 6 cardiomyopathic hamsters. quently observed in a generalized form, involvCalcium deposition was observed in mitochron- ing not only myocardium or cardiac arteries, dira after myocyte breakdown and disruption of but also aorta, renal, and gastric arteries, the sarcolemma as well as in interstitial areas. Min- basal laminae of the respiratory epithelium eralization was present in mitochondria as elec- (nasal cavity, larynx, trachea), walls ofthe brontron-dense granules and/or fine spicular de- chi and alveoli, and the basal membranes of the posits of varying quantity and distribution.
Novilla and Glen C. Todd Cardiotoxicity of Ionophores, Rat Focal myocardial necrosis with contraction bands is found in rats with gross changes of pale streaking or generalized pallor of the ventricular myocardium. Affected fibers are swollen and intensely stained by eosin or toluidine blue or appear fragmented and lysed with minimal to slight inflammation. Rats with congestive heart failure have diffuse sarcoplasmic vacuolation, interstitial edema, and attenuated fibers with or without small foci of necrosis and/or fibrosis in the myocardium (Fig.
Many of these strains are descendants of the oldest inbred mouse strain DBA (Rings and Wagner 1972), which also has the highest incidence of calcium deposits in the heart (Ayers and Jones 1978). Anatomic distribution of the lesions varies between the various affected mouse strains, with epicardial localization in BALB/c, myocardial involvement in CBH and C3 Hf, and both epicardial and myocardial lesions in DBAl2 (van Fleet and Ferrans 1986). References Ayers K, Jones SR (1978) The cardiovascular system.