Cardiovascular Biomarkers: Pathophysiology and Disease by Robert H. Christenson PhD, Hassan M. E. Azzazy PhD, DABCC

By Robert H. Christenson PhD, Hassan M. E. Azzazy PhD, DABCC (auth.), David A. Morrow MD, MPH (eds.)

So speedily has the variety of cardiac assays to be had grown, after which superior, that present biomarkers not just diagnose heart problems, but in addition body remedy techniques. In Cardiovascular Biomarkers: Pathophysiology and sickness administration, a individual panel of the world over well-known opinion makers and specialists in scientific and laboratory drugs synthesize the newest advancements within the use of cardiac biomarkers by way of the training healthcare professional. The authors specialize in integrating biomarkers into the modern medical administration of sufferers with heart problems, emphasizing scientific experiences, evidence-based diagnostic algorithms, and demanding pathways for triage and remedy, each time on hand. in addition they remove darkness from the connections among particular biomarkers and the fundamental pathophysiology of heart problems, clarify the analytical homes of the assays correct to medical perform, and spotlight rising biomarkers and novel instructions for biomarker improvement. a number of figures, illustrations, and tables make key facts and functional guidance simply accessible.
State-of-the-art and hugely functional, Cardiovascular Biomarkers: Pathophysiology and ailment administration makes transparent to ultra-modern busy cardiologists, emergency room physicians, and internists how a few of the assays practice, which of them they need to order while comparing their sufferers, and the way the result of a biomarker assay can advisor their healing approaches.

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16. Mair J, Thome-Kromer B, Wagner I, et al. Concentration time courses of troponin and myosin subunits after acute myocardial infarction. Coron Artery Dis 1994;5:865–872. 17. Hillis GS, Zhao N, Taggart P, Dalsey WC, Mangione A. Utility of cardiac troponin I, creatine kinaseMB(mass), myosin light chain 1, and myoglobin in the early in-hospital triage of “high risk” patients with chest pain. Heart 1999:82:614–620. 18. Katus HA, Diederich KW, Hoberg E, Kubler W. Circulating cardiac myosin light chains in patients with angina at rest: identification of a high risk subgroup.

20. Rosalki SB, Roberts R, Katus HA, Giannitsis E, Ladenson JH, Apple FS. Cardiac biomarkers for detection of myocardial infarction: perspectives from past to present. Clin Chem 2004;50:2205–2213. 21. Ladue JS, Wroblewski F, Karmen A. Serum glutamic oxaloacetic transaminase activity in human acute transmural myocardial infarction. Science 1954;120:497–499. 22. Warhol MJ, Siegel AJ, Evans WJ, Silverman LM. Skeletal muscle injury and repair in marathon runners after competition. Am J Pathol 1985;118:331–339.

Mol Cell Proteomics 2002;1:845–867. 76. Reynolds MA, Anderberg JM, Buechler KF, et al. A cardiac marker panel for the diagnosis of acute myocardial infarction. Clin Chem 2004;50:A22 (abstract). Chapter 2 / Clinical Use of Cardiac Troponin 2 27 Analytical Issues for Clinical Use of Cardiac Troponin Alan H. B. Wu, PhD CONTENTS INTRODUCTION RELEASE OF TROPONIN AFTER MYOCARDIAL INJURY QUALITY SPECIFICATIONS FOR ANALYTIC ASSAYS AMI CUTOFF CONCENTRATIONS AND ASSAY IMPRECISION FOR T ROPONIN CARDIAC TROPONIN CUTOFF FOR RISK STRATIFICATION PRE- AND POSTANALYTIC VARIABLES CONCLUSION REFERENCES SUMMARY Guidelines jointly developed by the European Society of Cardiology and the American College of Cardiology have established cardiac troponin (T or I) as the biomarker of choice for the diagnosis of acute coronary syndromes (ACSs) and risk stratification of patients who present with ischemic symptoms suggestive of ACS.

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