Cell Adhesion by E. Edward Bittar and David R. Colman (Eds.)

By E. Edward Bittar and David R. Colman (Eds.)

One prerequisite for the evolution of multicellular organisms used to be the discovery of mechanisms during which cells may adhere to each other. at some point soon in our heritage, dividing cells now not went their separate protozoic methods within the primordial oceans, yet in its place came upon that by means of retaining an organization, via sticking jointly yet now not fusing, a variety of evolutionary merits grew to become attainable. the following improvement of specialised tissues and organs relied on the elaboration of highly refined, regulatable cell-to-cell adhesion mechanisms that are identified to function in organic techniques as varied because the progress of the embryo, the immune reaction, the institution of connections among nerve cells, and arteriosclerosis, to call quite a few. even supposing we will basically wager on the ancestral mechanisms that fostered the 1st primitive intercellular unions, a few a thousand million years in the past, we now realize modern molecular "themes" with most likely historical origins that mediate cell-cell interactions. The chapters during this ebook function priceless, thought-provoking, yet now not exhaustive, commentaries on modern issues in the vast box of mobilephone adhesion. If the reader detects a moderate tilt towards these adhesion molecules that functionality within the apprehensive approach, this can be in simple terms a mirrored image of this editor's pursuits, biases, and naturally, boundaries.

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0 . 32 34 34 35 37 38 39 42 44 45 46 48 50 MARK A. JUTILA 32 D. Speculation of the Existence of a Family of High-affinity Selectin Ligands ......................... VIII. Future Research Directions on Selectins ....................... Acknowledgments References ....................................... 1. 51 52 52 52 INTRODUCTION Adhesive interactions between leukocytes and endothelial cells, leukocytes and other leukocytes, and leukocytes and platelets are required and occur in all types of inflammation.

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262, 8476-8482. F. (1992). Cloning and characterization of a gene that regulates cell adhesion. Nature 356, 529-532. Pytela, R. (1988). Amino acid sequence of the murine Mac-I a chain reveals homology with the integrin family and an additional domain related to von Willebrand factor. O. J. 7, 1371-1378. Reszka, A. F. (1992). Identification of amino acid sequences in the integrin PI cytoplasmic domain implicated in cytoskeletal association. J. Cell. Biol. 117, 1321-1329. P. (1989). Processing and assembly of the integrin, glycoprotein IIb-IIIa, in HEL cells.

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