Ceramide Signaling (Molecular Biology Intelligence Unit) by Anthony H. Futerman

By Anthony H. Futerman

The amount assembles present info at the function of ceramide as a signalling molecule in sixteen chapters written by way of prime staff during this sector. particular consciousness is given to mechanisms of research of ceramide and its biophysical homes, on enzymes of ceramide metabolism and down-stream objectives of ceramide, at the cross-talk of ceramide signalling with different signalling pathways, and at the function of ceramide in neuronal signalling. ultimately, the booklet closes with a piece at the healing implications of ceramide motion, within the parts of cannabinoid motion, chemotherapy, and atherosclerosis, and illustrates the aptitude clinical importance of delineating the jobs of ceramide in cellphone signalling. this is often the 1st quantity particularly dedicated to ceramide signalling, and should act as a useful source for simple and clinical researchers and graduate scholars wishing to get a state-of-the-art evaluation of this swiftly relocating box.

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Extra resources for Ceramide Signaling (Molecular Biology Intelligence Unit)

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Biophys J 2001; 80:765-775. 50. Israelachvili JN, Marcelja S, Horn RG. Physical principles of membrane organization. Q Rev Biophys 1980; 13:121-200. 51. Pascher I. Molecular arrangements in sphingolipids. Conformation and hydrogen bonding of ceramide and their implication on membrane stability and permeability. Biochim Biophys Acta 1976; 455:433-451. 52. Moore DJ, Rerek ME, Mendelsohn R. FTIR spectroscopy studies of the conformational order and phase behaviour of ceramides. J Phys Chem B 1997; 101:8933-8940.

19. Weiss B, Stoffel W. Human and murine serine-palmitoyl-CoA transferase. Cloning, expression and characterization of the key enzyme in sphingolipid synthesis. Eur J Biochem 1997; 249:237-247. 20. Huwiler A, Kolter T, Pfeilschifter J et al. Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim Biophys Acta 2000; 1485:63-99. 21. Holopainen JM, Subramaniam M, Kinnunen PKJ. Sphingomyelinase induced lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane.

This review compiles relevant currently available data on the biophysical properties of ceramide and the impact this lipid imparts on model membranes. Together with recent insights derived from cell biological approaches, potential mechanisms and events can be delineated at the molecular level. Topology of Ceramide Formation In eukaryotic cells ceramide is formed by the hydrolysis of the ubiquitous SM by sphingomyelinase (SMase)2,18 or, alternatively, by de novo synthesis of ceramide. Both pathways are used in signaling, the major difference being the time course of their action.

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