By Anthony H. Futerman
The amount assembles present info at the function of ceramide as a signalling molecule in sixteen chapters written by way of prime staff during this sector. particular consciousness is given to mechanisms of research of ceramide and its biophysical homes, on enzymes of ceramide metabolism and down-stream objectives of ceramide, at the cross-talk of ceramide signalling with different signalling pathways, and at the function of ceramide in neuronal signalling. ultimately, the booklet closes with a piece at the healing implications of ceramide motion, within the parts of cannabinoid motion, chemotherapy, and atherosclerosis, and illustrates the aptitude clinical importance of delineating the jobs of ceramide in cellphone signalling. this is often the 1st quantity particularly dedicated to ceramide signalling, and should act as a useful source for simple and clinical researchers and graduate scholars wishing to get a state-of-the-art evaluation of this swiftly relocating box.
Read Online or Download Ceramide Signaling (Molecular Biology Intelligence Unit) PDF
Similar anatomy & physiology books
The most target of this booklet is to explain in actual phrases the abnormal good points of "machines" having molecular dimensions that play the valuable position within the most crucial organic techniques, viz. , power transduction and enzyme catalysis. for the reason that those molecular engines paintings with thermal, chemical, and mechanical strength, the suitable framework to debate them comes from thermodynamics and chemical kinetics.
Jean-Marie Denoix is the world’s major equine musculoskeletal method anatomist and has turn into one of many most desirable equine diagnostic ultrasonographers. there's consequently not anyone higher to assemble a reference atlas of the scientific anatomy of the foot, pastern and fetlock, correlated with photographs received by means of radiography, diagnostic ultrasonography and magnetic resonance imaging.
This quantity encompasses a complete choice of tools for the isolation of platelet membranes, subcellular organelles, the cytoskeleton, and for the assay and purification of platelet receptors. Key gains* Platelets are mobile parts with the top density of receptors consistent with membrane floor region curious about binding of adhesive molecules, clotting, enzymes, and vasoactive amines* Platelets are crucial for the arrest of bleeding and for formation of intravascular thrombi contributing to center assaults, strokes, and disseminated intravascular coagulation, and are fascinated with immune advanced sickness* Platelets are important for learning the approaches of telephone adhesion, neurotransmitter uptake, stimulus-response coupling, together with sign transduction and secretion
This quantity is predicated at the NATO complex examine Institute, "Advances in Mor phometries" held in eleven Ciocco, Tuscany, Italy from July 18-30, 1993, and directed by way of Leslie F. Marcus. The "Advances in Morphometries" ASI used to be marketed in Nature and a few expert journals. bulletins have been despatched to appropriate associations and departments through the global.
- Proteolytic Enzymes: Serine and Cysteine Peptidases
- Experimentelle Pflanzenphysiologie: Band 2 Einführung in die Anwendungen
- Metaepistemology and Skepticism
- Problem-Based Anatomy
- How the Brain Got Language: The Mirror System Hypothesis (Oxford Studies in the Evolution of Language, Volume 16)
- Modern Techniques In Neuroscience Research Windhorst Johansson
Extra resources for Ceramide Signaling (Molecular Biology Intelligence Unit)
Biophys J 2001; 80:765-775. 50. Israelachvili JN, Marcelja S, Horn RG. Physical principles of membrane organization. Q Rev Biophys 1980; 13:121-200. 51. Pascher I. Molecular arrangements in sphingolipids. Conformation and hydrogen bonding of ceramide and their implication on membrane stability and permeability. Biochim Biophys Acta 1976; 455:433-451. 52. Moore DJ, Rerek ME, Mendelsohn R. FTIR spectroscopy studies of the conformational order and phase behaviour of ceramides. J Phys Chem B 1997; 101:8933-8940.
19. Weiss B, Stoffel W. Human and murine serine-palmitoyl-CoA transferase. Cloning, expression and characterization of the key enzyme in sphingolipid synthesis. Eur J Biochem 1997; 249:237-247. 20. Huwiler A, Kolter T, Pfeilschifter J et al. Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim Biophys Acta 2000; 1485:63-99. 21. Holopainen JM, Subramaniam M, Kinnunen PKJ. Sphingomyelinase induced lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane.
This review compiles relevant currently available data on the biophysical properties of ceramide and the impact this lipid imparts on model membranes. Together with recent insights derived from cell biological approaches, potential mechanisms and events can be delineated at the molecular level. Topology of Ceramide Formation In eukaryotic cells ceramide is formed by the hydrolysis of the ubiquitous SM by sphingomyelinase (SMase)2,18 or, alternatively, by de novo synthesis of ceramide. Both pathways are used in signaling, the major difference being the time course of their action.