CNS Pharmacology Neuropeptides. Proceedings of the 8th by H. Yoshida

By H. Yoshida

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As can be seen, the molar ratio of activity ranges over nearly three orders of magni­ tude, with ß-endorphin and metkephamid being the most potent reported here and met-enkephalin being among the least active of the agonists. 5 to 1 mg/kg naloxone admini­ stered intraperitoneally. A limited number of drugs have been studied in greater detail. In these experiments, dose response curves to intrathecally administered agonists were carried out in the presence of increasing doses of systemically administered naloxone.

1980) J. Pharmacol. Exp. , 15, 626-632. C. A. (1980) J. Pharmacol. Exp. , 1_5, 633-642. Zieglgansberger, W. and Bayerl, H. , 115, 111-128. Intrathecal Use of Beta-Endorphin as a Powerful Analgetic Agent in Man T. Oyama*, T. Jin*, R. Yamaya*, A. Matsuki*, N. Ling** and R. Guillemin** *Dept. of Anesthesia, Hirosaki University School of Medicine, Hirosaki City, Aomori, Japan **Salk Institute, La Jolla, San Diego, California, USA ABSTRACT In this study, synthesized ^-endorphin was injected in patients with cancer pain and the obstetrical patients who underwent vaginal delivery.

1 stabl e ~·ΓΑΙΓ~ t stable ^ stabl e stabl e -, (-) (-) stabl e stabl e I stabl e j stabl e ! (+) stabl e j (+) stabl e stabl e I 1 1 Summary of clinical data in 14 obstetrical patients who received one intrathecal injection of ß-endorphin. BPiblood pressure, PR:pulse rate, ECG:electrocard-orgam. 1 T. Oyama et 42 dl. 6 cm (range from 4 cm to 10 cm). The time from injection to delivery was 103+21 min, ranging from 19 min to 260 min. 5 min after the injection of ß-endorphin, although feeling of pressure over the lower abdomen and of resistance over the rectovaginal region at the time of the uterine contractions remained unchanged.

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