Congenital Heart Disease - A Medical Dictionary, by Icon Health Publications

By Icon Health Publications

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Extra info for Congenital Heart Disease - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

Sample text

In fact, congenital heart disease is a leading cause of death during the first year of life. The acute care cost of treating these infants each year, exceeds $400,000,000. This estimate does not include the chronic care costs of clinic visits, medications, and rehabilitation. The program expands the current three-year fellowship training program to four years by adding an additional research year -- either in clinical or basic science research. Furthermore, it enhances the current one by offering trainees access to a wide range of additional Duke research resources and, thus, potential mentors.

Professor; Pediatrics; University of Iowa Iowa City, Ia 52242 Timing: Fiscal Year 2002; Project Start 01-AUG-1996; Project End 31-JUL-2007 Summary: (provided by applicant): BBS is an autosomal recessive disorder characterized by retinal degeneration, obesity, polydactyly, mental retardation, renal anomalies, and hypogonadism. In addition, BBS is associated with an increased incidence of diabetes mellitus, hypertension and congenital heart disease. Over the past few years, we and others have demonstrated that the disorder is genetically heterogeneous and is caused by at least six independent loci.

Hypoxic encephalopathy is the most common cause of neonatal seizures, and can lead to epilepsy, cerebral palsy, and mental retardation. Therapies to prevent such long-term adverse outcomes do not yet exist, as their development requires more thorough knowledge of the pathological cellular and molecular changes in brain function that result from neonatal hypoxic encephalopathy. Using a rat model, we have obtained evidence for long-lasting pathological changes in GABA-A receptor-mediated inhibitory synaptic transmission in hippocampal CA1 pyramidal neurons following neonatal hypoxia-induced seizures.

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