By John V Forrester MD, Lucia Kuffova
This publication offers a precis of a few of the features of corneal transplantation — the scientific, experimental (including multimedia demonstrate of the surgical techniques), immunological, healing and prosthetic parts — in a single quantity. The expert in a single box can therefore have entry to info from the opposite fields and improve a huge notion of the demanding situations to be confronted achieve the last word target, i.e. an optically transparent, visually passable, functioning corneal graft that is tolerated within the long-term with no the necessity for systemic immunosuppression. A moment goal of the publication is to supply information about present immunological thoughts of the method of corneal graft rejection. particularly, contemporary paintings within the fields of innate as opposed to adaptive immunity, novel therapeutics and corneal xenografts is gifted.
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Extra info for Corneal Transplantation: An Immunological Guide to the Clinical Problem
Cornea 1995; 14(1): 43. The Clinical Problem 45 20. Maumenee AE. T h e Pocklington lecture, 1976: Recent advances in corneal transplantation. Trans Ophthalmol Soc UK 1976; 46(4): 462. 21. Katami M Corneal transplantation—immunologically privileged status. Eye 1991; 5 (Pt 5): 528. 22. Khodadoust AA and Silverstein AM. Studies on the nature of the privilege enjoyed by corneal allografts. Invest Ophthalmol 1972; 11(3): 137. 23. Gourishankar S et al. Jy4m Soc Nephrol 2003; 14(2): 493. Q Eye Banking Introduction During the last 50 years advances in corneal tissue harvesting, preservation and distribution under the supervision of a worldwide network of eye banks allowed an increase in the numbers of surgeons performing fullthickness penetrating keratoplasties and also helped to prolong survival of such treated corneal grafts.
3) had active ocular or intraocular inflammation, congenital or acquired conditions, which could preclude a successful outcome of penetrating keratoplasty and pterygia, which involve central cornea. (4) had a history of refractive surgery or laser photoablative surgery. If there was previous surgery to the anterior segment of the eye (cataract and antiglaucoma surgery), the cornea needs to be screened by specular microscopy and endothelial viability needs to meet standards of the eye bank. (5) may have contracted a prion-induced disease, including confirmed and suspected cases of Creutzfeldt—Jakob Disease (QJD), and nonvariant CJD, progressive multifocal leukoencephalopathy, the human form of bovine spongiform encephalopathy, or so-called "mad cow" disease.
10. Jain S and Azar DT. N e w lamellar keratoplasty techniques: posterior keratoplasty and deep lamellar keratoplasty. Curr Opin Ophthalmol 2001; 12(4): 262. 11. Trimarchi F, Poppi E and Klersy C. Deep lamellar keratoplasty. J Fr Ophthalmol 2002; 25(7): 718. 12. Sugita J and Kondo J. Deep lamellar keratoplasty with complete removal of pathological stroma for vision improvement. Br J Ophthalmol 1997; 81(3): 184. 13. Krumeich J H and Daniel J. Live epikeratophakia and deep lamellar keratoplasty for I—III stage-specific surgical treatment of keratokonus.