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Additional resources for Dilated Cardiomyopathy - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
Therefore, in the mouse model of Chagas' disease the kinetics of expression of cell cycle regulatory proteins in the cells of the myocardium of T. cruzi-infected mice will be determined and correlated with progression of cardiomyopathy. The mechanisms underlying the alterations in these proteins in the myocardium will be investigated by a variety of techniques including immune complex assays and cell proliferation experiments. d3 and ET-1 have been selectively deleted from cardiac myocytes. These studies will lead to a better understanding of cardiac remodeling in chagasic cardiomyopathy, an emerging opportunistic infection in AIDS.
Subsequent to immunosuppression there is reactivation of dormant organisms leading to myocarditis and necrotizing encephalitis. Since HIV-infected patients receiving HAART live for many years there is the likelihood that there will be repeated episodes of reactivation as their immune status waxes and wanes. Hence, progressive myocarditis and cardiovascular remodeling and chronic cardiomyopathy will likely develop in a more rapid fashion. In this application we have defined ventricular remodeling as changes in structure and function following myocardial damage together with characteristic molecular changes.
Over the past 12 years since the last NHLBI-sponsored workshop on this subject, there has been increasing evidence that abnormalities in cellular and humoral immunity contribute to the pathogenesis of DCM. However, these advances in the understanding of the pathogenesis and pathophysiology of DCM have not affected clinical diagnosis and treatment. Therefore, it is timely to organize a workshop to review the advances of the past decade in cardiac immunopathology as they impact the diagnosis and treatment of DCM.