Viral Membrane Proteins: Structure, Function, and Drug by Wolfgang B. Fischer

By Wolfgang B. Fischer

In Viral Membrane Proteins: constitution, functionality, and Drug layout, Wolfgang Fischer summarizes the present structural and sensible wisdom of membrane proteins encoded via viruses. moreover, participants to the publication deal with questions on proteins as power drug ambitions. the variety of data coated contains sign proteins, ion channels, and fusion proteins. This booklet has a spot within the libraries of researchers and scientists in a big selection of fields, together with protein chemistry, molecular biophysics, pharmaceutical technology and study, bioanotechnology, molecular biology, and biochemistry.

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Viral Membrane Proteins: Structure, Function, and Drug Design (Protein Reviews)

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Extra resources for Viral Membrane Proteins: Structure, Function, and Drug Design (Protein Reviews)

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Influenza virus M2protein has ion channel activity. Cell 69, 517–528. A. (1998). Extracellular HIV-1 virus protein R causes a large inward current and cell death in cultured hippocampal neurons: Implications for AIDS pathology. Proc. Natl. Acad. Sci. USA 95, 4595–4600. B. (1999). The amino-terminal region of Vpr from human immunodeficient virus Type 1 forms ion channels and kills neurons. J. Virol. 73, 4230–4238. , Derst, C. et al. (2000). A potassium channel protein encoded by chlorella virus PBCV-1.

For the early phase of infection, we hypothesize that after digestion of the cell wall, the viral membrane fuses with the host plasma membrane. This fusion of the Kcv containing viral membrane with the high resistance host membrane increases the Kϩ conductance of the host membrane. The resulting membrane depolarization might prevent membrane fusion by a second virus, thus inhibiting infection by a second virus. , 2003). Depolarization is host specific and its time course is correlated with the number of infecting viruses.

S. Clark, O. D. Evans, J. Jaeger, et al. (2003). FEBS Lett. 535, 34–38. , and MacKinnon, R. (1994). Mutations in the Kϩ channel signature sequence. Biophys. J. 66, 1061–1067. Hille, B. (2001). Ion Channels of Excitable Membranes, 3nd edn. , Sunderland, MA. , and MacKinnon, R. (2002). Crystal structure and mechanism of a calcium-gated potassium channel. Nature 417, 515–522. T. et al. (2003). X-ray structure of a voltage-dependent Kϩ channel. Nature 423, 33–41. V. (2002). 14-3-3 amplifies and prolongs adrenergic stimulation of HERG Kϩ channel activity.

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